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Article

The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.

Nucleic acids research - 9 Sept 2024

Li Xiao, Perdomo Ivette Maria Menendez, Rodrigues Alves Barbosa Victoria, Diao Catherine, Tarailo-Graovac Maja

Abstract excerpt

FANCJ/BRIP1, initially identified as DOG-1 (Deletions Of G-rich DNA) in Caenorhabditis elegans, plays a critical role in genome integrity by facilitating DNA interstrand cross-link repair and resolving G-quadruplex structures. Its function is tightly linked to a conserved [4Fe-4S] cluster-binding motif, mutations of which contribute to Fanconi anemia and various cancers. This study investigates the critical role...

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Identifiers

PMID: 39011897
DOI: 10.1093/nar/gkae617
PMCID: PMC11381322

Genes

BRIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.PMID 39011897Read ↗

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