Article
Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans.
Genetics - 1 Jun 2006
Youds Jillian L, O'Neil Nigel J, Rose Ann M
Abstract excerpt
In C. elegans, DOG-1 prevents deletions that initiate in polyG/polyC tracts (G/C tracts), most likely by unwinding secondary structures that can form in G/C tracts during lagging-strand DNA synthesis. We have used the dog-1 mutant to assay the in vivo contribution of various repair genes to the maintenance of G/C tracts. Here we show that DOG-1 and the BLM ortholog, HIM-6, act synergistically during replication;...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.