Article
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA.
Nature genetics - 1 Aug 2002
Cheung Iris, Schertzer Michael, Rose Ann, Lansdorp Peter M
Abstract excerpt
Genetic integrity is crucial to normal cell function, and mutations in genes required for DNA replication and repair underlie various forms of genetic instability and disease, including cancer. One structural feature of intact genomes is runs of homopolymeric dC/dG. Here we describe an unusual mutator phenotype in Caenorhabditis elegans characterized by deletions that start around the 3' end of polyguanine tracts...
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