Article
Spectrum of mutational events in the absence of DOG-1/FANCJ in Caenorhabditis elegans.
DNA repair - 1 Nov 2008
Zhao Yang, Tarailo-Graovac Maja, O'Neil Nigel J, Rose Ann M
Abstract excerpt
The Caenorhabditis elegans ortholog of the Fanconi anemia pathway component J (FANCJ) is DOG-1, which is essential for genome stability. Previous studies have shown that disruption of the dog-1 gene generates small deletions of poly-C/poly-G tracts detectable by PCR and results in a mutator phenotype. In this paper, we describe the isolation and characterization of lethal mutations resulting from the loss of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.