Article
Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation.
BMC genomics - 18 Mar 2015
Tarailo-Graovac Maja, Wong Tammy, Qin Zhaozhao, Flibotte Stephane, Taylor Jon, Moerman Donald G, Rose Ann M, Chen Nansheng
Abstract excerpt
BACKGROUND: Whole and partial chromosome losses or gains and structural chromosome changes are hallmarks of human tumors. Guanine-rich DNA, which has a potential to form a G-quadruplex (G4) structure, is particularly vulnerable to changes. In Caenorhabditis elegans, faithful transmission of G-rich DNA is ensured by the DOG-1/FANCJ deadbox helicase. RESULTS: To identify a spectrum of mutations, after long-term...
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