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Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes.

BMC medical genomics - 15 Jul 2024

Urzúa-Traslaviña Carlos G, van Lieshout Tijs, Boulogne Floranne, Domanegg Kevin, Zidan Mahmoud, Bakker Olivier B, Claringbould Annique, de Ridder Jeroen, Zwart Wilbert, Westra Harm-Jan, Deelen Patrick, Franke Lude

Abstract excerpt

BACKGROUND: The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer have revealed many germline risk factors associated with cancer. However, the overlap between known somatic driver genes and positional candidate genes from GWAS loci is surprisingly small. We...

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Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39010058
DOI: 10.1186/s12920-024-01941-4
PMCID: PMC11247850

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