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Article

Modulation of purinergic signaling in endothelial cells by tumor microenvironment.

Vascular pharmacology - 1 Jun 2024

Chinigò Giorgia, Scarpellino Giorgia, Petrillo Sara, Genova Tullio, Ruffinatti Federico Alessandro, Munaron Luca

Abstract excerpt

Purinergic signaling plays a crucial role in vascular endothelium functions. In particular, ionotropic P2X receptors (P2XRs) are engaged in various intracellular pathways through which endothelial cells (ECs) adapt to external stimuli. However, very little is known about the impact of P2XRs on vascular remodeling during carcinogenesis. We previously demonstrated that high purinergic stimulation impairs the...

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Identifiers

PMID: 38985614
DOI: 10.1016/j.vph.2024.107311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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