Extracellular ATP drives pancreatic cancer cell invasion via purinergic receptor-integrin interactions

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a cancer of unmet clinical need. Given the elevated ATP levels seen in PDAC, the purinergic axis represents an attractive therapeutic target. Mediated in part by highly druggable extracellular proteins, it plays essential roles in fibrosis, inflammation response and immune function. We have analysed the PDAC purinome using publicly available databases to discern which mem...

Topics

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• Adenosine and Purinergic Signaling
• Barrier Structure and Function Studies
• Cancer Genomics and Diagnostics
• Cancer, Hypoxia, and Metabolism
• Neuroendocrine Tumor Research Advances
• Pancreatic and Hepatic Oncology Research
• Pancreatic function and diabetes
• Radiomics and Machine Learning in Medical Imaging

Identifiers and source

Literature Corpus work

1f7fd73d-4d57-548c-bc01-bb232c6f7282

DOI

10.1101/2022.10.24.513477