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Generation of an induced pluripotent stem cell line (CSBZZUi001-A) from a female Alzheimer's patient carrying the PSEN1 709 T > C heterozygous mutation.

Stem cell research - 1 Sept 2024

Meng Xiao-Yan, Sun Hui-Fang, Zhang Ying-Jie, Li Wen-Xiu, Wang Dian-Dian, Liu Dan-Hua, Li Sen-Miao, Wu Yue, Li Jia-Kang, Liu Xiao-Hui, Liu Pei-Pei, Yang Run-Zhou, Li Shu-Ang, Kang Jian-Sheng

Abstract excerpt

Pluripotent stem cells were generated through the electroporation of episomal plasmids, containing crucial reprogramming factors, into skin fibroblasts extracted from a female Alzheimer's patient harboring the PSEN1 709 T > C (p.Phe237Leu) heterozygous mutation. The pluripotent stem cells exhibit a normal karyotype and express pivotal stem cell markers including TRA-1-60, Nanog, SOX2, and OCT4. Furthermore, their...

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Identifiers

PMID: 38968760
DOI: 10.1016/j.scr.2024.103486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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