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Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n = 3) and sex- and age-matched healthy controls (n = 3).

Stem cell research - 1 May 2021

Raska Jan, Hribkova Hana, Klimova Hana, Fedorova Veronika, Barak Martin, Barta Tomas, Pospisilova Veronika, Vochyanova Simona, Vanova Tereza, Bohaciakova Dasa

Abstract excerpt

Human induced pluripotent stem cell (iPSC) lines were generated from primary human fibroblasts isolated from three patients with a familial form of Alzheimer's disease (AD) and three healthy control individuals. Two AD-iPSC lines carry a PSEN1 mutation A246E; the third cell line carries a PSEN2 mutation N141I. The fibroblasts were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5...

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Identifiers

PMID: 34088008
DOI: 10.1016/j.scr.2021.102379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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