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Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1.

Stem cell research - 1 Mar 2016

Li Tong, Pires Carlota, Nielsen Troels T, Waldemar Gunhild, Hjermind Lena E, Nielsen Jørgen E, Dinnyes Andras, Hyttel Poul, Freude Kristine K

Abstract excerpt

Skin fibroblasts were obtained from a 48-year-old presymptomatic woman carrying a A79V mutation in the presenilin 1 gene (PSEN1), causing Alzheimer's disease (AD). Induced pluripotent stem cell (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2, hL-MYC, hLIN28 and shTP53 genes. A79V-iPSCs were free of genomically integrated reprogramming genes, had the specific mutation but...

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Identifiers

PMID: 27345973
DOI: 10.1016/j.scr.2016.01.002

Genes

PSEN1
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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