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Article

Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes.

Frontiers in immunology - 1 Jan 2024

Guggemos Johanna, Fuller Stephen J, Skarratt Kristen K, Mayer Benjamin, Schneider E Marion

Abstract excerpt

Introduction: Extracellular ATP (eATP) released from damaged cells activates the P2X7 receptor (P2X7R) ion channel on the surface of surrounding cells, resulting in calcium influx, potassium efflux and inflammasome activation. Inherited changes in the P2X7R gene (P2RX7) influence eATP induced responses. Single nucleotide polymorphisms (SNPs) of P2RX7 influence both function and signaling of the receptor, that in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38966639
DOI: 10.3389/fimmu.2024.1352789
PMCID: PMC11222724

Genes

P2RX7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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