Article
P2RX7 genotype association in severe sepsis identified by a novel Multi-Individual Array for rapid screening and replication of risk SNPs.
Clinica chimica acta; international journal of clinical chemistry - 18 Jan 2012
Geistlinger J, Du W, Groll J, Liu F, Hoegel J, Foehr K J, Pasquarelli A, Schneider E M
Abstract excerpt
BACKGROUND: Functional single nucleotide polymorphisms (SNPs) are relevant to individual therapeutic approaches and may play a role in disease susceptibility. Genome-wide scans, which are now widely applied to detect disease-associated SNPs, provide only limited evidence about SNP associations. Their usefulness as disease markers requires appropriate phenotype analysis and retesting of the gene providing SNP...
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