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Article

Regulation of the Acute Sickness Response by the P2RX7 Receptor.

The Journal of infectious diseases - 1 Sept 2021

Li Hui, Cvejic Erin, Gu Ben, Vollmer-Conna Ute, Hickie Ian, Wakefield Denis, Davenport Tracey, Wiley James, Lloyd Andrew R

Abstract excerpt

BACKGROUND: The acute sickness response to infection is a stereotyped set of illness manifestations initiated by proinflammatory signals in the periphery but mediated centrally. P2RX7 is a highly polymorphic gene encoding an ATP-gated cationic pore, widely expressed on immune cells and the brain, and regulating the NLRP3 inflammasome, as well as diverse neural functions. METHODS: Associations between P2RX7...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-1beta

Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Share to Receptors, Purinergic P2X7

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Identifiers

PMID: 33471105
DOI: 10.1093/infdis/jiab027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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