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Article

Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination

4 Jul 2024

Abstract excerpt

Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelination in miR-145 knockout mice to determine its contributions to remyelination failure. Following acute demyelination, no advantage to miR-145 loss could be detected. However,...

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PMID: 38965401
DOI: 10.1038/s42003-024-06513-x

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