Article

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

2024-08-04

Abstract excerpt

Approximately 40% ERα-positive breast cancer patients suffer from therapeutic resistance to tamoxifen. Although reduced ERα level is the major cause of tamoxifen resistance, the underlying mechanisms remain elusive. Here, we report that FRMD8 raises the level of ERα at both transcriptional and post-translational layers. FRMD8 deficiency in MMTV-Cre + ; Frmd8 fl/fl ; PyMT mice accelerates mammary tumor growth a...

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Literature Corpus work: 2b179d3c-0afb-5713-a663-4d808e6054c8
DOI: 10.1101/2024.08.01.606147

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