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Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry.

Neurobiology of aging - 1 Jan 2024

Nuytemans Karen, Rajabli Farid, Jean-Francois Melissa, Kurup Jiji Thulaseedhara, Adams Larry D, Starks Takiyah D, Whitehead Patrice L, Kunkle Brian W, Caban-Holt Allison, Haines Jonathan L, Cuccaro Michael L, Vance Jeffery M, Byrd Goldie S, Beecham Gary W, Reitz Christiane, Pericak-Vance Margaret A

Abstract excerpt

There is a paucity of genetic studies of Alzheimer Disease (AD) in individuals of African Ancestry, despite evidence suggesting increased risk of AD in the African American (AA) population. We performed whole-genome sequencing (WGS) and multipoint linkage analyses in 51 multi-generational AA AD families ascertained through the Research in African American Alzheimer Disease Initiative (REAAADI) and the National...

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Identifiers

PMID: 37952397
DOI: 10.1016/j.neurobiolaging.2023.10.010
PMCID: PMC11131578

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