Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans.

doi:10.1002/alz.12865

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Article

Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2023

Rajabli Farid, Tosto Giuseppe, Hamilton-Nelson Kara L, Kunkle Brian W, Vardarajan Badri N, Naj Adam, Whitehead Patrice G, Gardner Olivia K, Bush William S, Sariya Sanjeev, Mayeux Richard P, Farrer Lindsay A, Cuccaro Michael L, Vance Jeffrey M, Griswold Anthony J, Schellenberg Gerard D, Haines Jonathan L, Byrd Goldie S, Reitz Christiane, Beecham Gary W, Pericak-Vance Margaret A, Martin Eden R

Abstract excerpt

BACKGROUND: This study used admixture mapping to prioritize the genetic regions associated with Alzheimer's disease (AD) in African American (AA) individuals, followed by ancestry-aware regression analysis to fine-map the prioritized regions. METHODS: We analyzed 10,271 individuals from 17 different AA datasets. We performed admixture mapping and meta-analyzed the results. We then used regression analysis,...

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Identifiers

PMID: 36539198
DOI: 10.1002/alz.12865
PMCID: PMC10272044

Genes

BCL2
KIF1C
MINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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