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Article

Genetic Markers of Postmortem Brain Iron.

Journal of neurochemistry - 1 Feb 2025

Cornelis Marilyn C, Fazlollahi Amir, Bennett David A, Schneider Julie A, Ayton Scott

Abstract excerpt

Brain iron (Fe) dyshomeostasis is implicated in neurodegenerative diseases. Genome-wide association studies (GWAS) have identified plausible loci correlated with peripheral levels of Fe. Systemic organs and the brain share several Fe regulatory proteins but there likely exist different homeostatic pathways. We performed the first GWAS of inductively coupled plasma mass spectrometry measures of postmortem brain Fe...

Read the complete abstract on PubMed

Topics

Humans
Iron
Polymorphism, Single Nucleotide
Male
Female
Genome-Wide Association Study
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Brain

Aged, 80 and over

Genetic Markers

Middle Aged

Autopsy

Source

Open in PubMed Open full text

Identifiers

PMID: 39918201
DOI: 10.1111/jnc.16309
PMCID: PMC11804167

Genes

CLTC
COQ5
HS3ST1
HS3ST4
LONP1
PANK3
PINK1
PPIF
SLC25A11
SLC5A6
SORCS2
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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