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Article

Machine learning-based classification reveals distinct clusters of non-coding genomic allelic variations associated with Erm-mediated antibiotic resistance.

mSystems - 23 Jul 2024

Tan Yongjun, Le Scornet Alexandre, Yap Mee-Ngan Frances, Zhang Dapeng

Abstract excerpt

The erythromycin resistance RNA methyltransferase (erm) confers cross-resistance to all therapeutically important macrolides, lincosamides, and streptogramins (MLS phenotype). The expression of erm is often induced by the macrolide-mediated ribosome stalling in the upstream co-transcribed leader sequence, thereby triggering a conformational switch of the intergenic RNA hairpins to allow the translational...

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Identifiers

PMID: 38953319
DOI: 10.1128/msystems.00430-24
PMCID: PMC11264731

Genes

AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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