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Article

Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress.

mBio - 13 May 2026

Le Scornet Alexandre, Tan Yongjun, Zhang Dapeng, Wang Jue D, Yap Mee-Ngan F

Abstract excerpt

Macrolide, lincosamide, and streptogramin (MLS) antibiotics are structurally distinct molecules that inhibit protein synthesis by binding overlapping sites within the 23S rRNA of bacterial ribosomes. The clinical utility of MLS antibiotics has diminished due to the dissemination of erythromycin resistance rRNA methyltransferase (Erm) genes. Staphylococcus aureus ErmB methylates the universally conserved A2058...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41972768
DOI: 10.1128/mbio.00118-26
PMCID: PMC13170274

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