Article

Methyltransferase Erm(37) Slips on rRNA to Confer Atypical Resistance in Mycobacterium tuberculosis

2005-09-21

Abstract excerpt

Members of the Mycobacterium tuberculosis complex possess a resistance determinant, erm (37) (also termed erm MT), which is a truncated homologue of the erm genes found in a diverse range of drug-producing and pathogenic bacteria. All erm genes examined thus far encode N 6 -monomethyltransferases or N 6 , N 6 -dimethyltransferases that show absolute specificity for nucleotide A2058 in 23 S rRNA. Monomethylation at...

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Literature Corpus work: f5bece1a-365f-5dcf-b7bd-2c6281aa948e
DOI: 10.1074/jbc.m505727200

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