Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efflux pump activation confers mupirocin resistance and enhances rhizosphere fitness in Pseudomonas.

Applied and environmental microbiology - 20 May 2026

Wang Wen-Jie, Wang Man-Jin, Jiang Wen-Jun, Zhang Li-Qun

Abstract excerpt

Mupirocin (Mup) is a polyketide antibiotic for clinical methicillin-resistant Staphylococcus aureus treatment and agricultural biocontrol, acting by binding to IleRS to inhibit protein synthesis. Here, we demonstrate that Pseudomonas viciae 11K1 acquires resistance to mupirocin not through canonical mutations in ileS, the gene encoding the drug target, but via single-nucleotide polymorphisms (SNPs) of EmhR, a...

Topics

Join the communities discussing this publication.

Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Bacterial
Membrane Transport Proteins
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42017668
DOI: 10.1128/aem.02575-25
PMCID: PMC13188873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efflux pump activation confers mupirocin resistance and enhances rhizosphere fitness in Pseudomonas.PMID 42017668Read ↗

Efflux Pump Activation Confers Mupirocin Resistance and Enhances Rhizosphere Fitness in <i>Pseudomonas</i>Semantic proximity Read ↗

Exploring mechanisms of mupirocin resistance and hyper-resistanceSemantic proximity Read ↗

Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon LibrariesSemantic proximity Read ↗

Strain-resolved CRISPRi-Seq reveals conserved antibiotic vulnerabilities in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureusSemantic proximity Read ↗

VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus InfectionSemantic proximity Read ↗

Associations among Antibiotic and Phage Resistance Phenotypes in Natural and Clinical Escherichia coli Isolates.Semantic proximity Read ↗

Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in <i>Enterococcus faecium</i>Semantic proximity Read ↗

Mutations in bdcA and valS Correlate with Quinolone Resistance in Wastewater Escherichia coli.Semantic proximity Read ↗

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysisSemantic proximity Read ↗

The development of variation-based rifampicin resistance in Staphylococcus aureus deciphered through genomic and transcriptomic study.Semantic proximity Read ↗

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.