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Article

Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.

Nucleic acids research - 15 Aug 2003

Maravić Gordana, Bujnicki Janusz M, Feder Marcin, Pongor Sándor, Flögel Mirna

Abstract excerpt

The Erm family of adenine-N(6) methyltransferases (MTases) is responsible for the development of resistance to macrolide-lincosamide-streptogramin B antibiotics through the methylation of 23S ribosomal RNA. Hence, these proteins are important potential drug targets. Despite the availability of the NMR and crystal structures of two members of the family (ErmAM and ErmC', respectively) and extensive studies on the...

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Identifiers

PMID: 12907737
DOI: 10.1093/nar/gkg666
PMCID: PMC169915

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Source receipt: pubmed, retrieved 7 Sept 2026.

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