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Article

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.

Nature - 24 Aug 2017

Zhou Qiangjun, Zhou Peng, Wang Austin L, Wu Dick, Zhao Minglei, Südhof Thomas C, Brunger Axel T

Abstract excerpt

Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins mediate evoked synchronous neurotransmitter release, but the molecular mechanisms mediating the cooperation between these molecules remain unclear. Here we determine crystal structures of the primed pre-fusion SNARE-complexin-synaptotagmin-1 complex. These structures reveal an unexpected...

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Share to Adaptor Proteins, Vesicular Transport
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28813412
DOI: 10.1038/nature23484
PMCID: PMC5757840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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