Article
Complexins living up to their name--new light on their role in exocytosis.
Neuron - 12 Nov 2009
Stein Alexander, Jahn Reinhard
Abstract excerpt
Ca(2+)-dependent exocytosis of synaptic vesicles is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin. SNARE function is controlled by conserved regulatory proteins, including the complexins. In a study by Xue et al. in this issue of Neuron, contradictory data from Drosophila and mouse complexin mutants have been resolved, revealing a complex pattern of facilitatory and inhibitory domains.
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