Article
Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant.
Molecular and cellular neurosciences - 1 Sept 2013
Iyer Janani, Wahlmark Christopher J, Kuser-Ahnert Giselle A, Kawasaki Fumiko
Abstract excerpt
The COMPLEXIN (CPX) proteins play a critical role in synaptic vesicle fusion and neurotransmitter release. Previous studies demonstrated that CPX functions in both activation of evoked neurotransmitter release and inhibition/clamping of spontaneous synaptic vesicle fusion. Here we report a new cpx mutant in Drosophila melanogaster, cpx(1257), revealing spatially defined and separable pools of CPX which make...
Topics
- Adaptor Proteins, Vesicular Transport
- Animals
- Binding Sites
- Drosophila melanogaster
- Excitatory Postsynaptic Potentials
- Exocytosis
- Mutation
- Neuromuscular Junction
- Protein Binding
- Protein Transport