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Article

DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil.

Blood cells, molecules & diseases - 1 Dec 2014

Cardoso Greice Lemos, Diniz Isabela Guerreiro, Silva Aylla Núbia Lima Martins da, Cunha Daniele Almeida, Silva Junior Josivaldo Soares da, Uchôa Camila Tavares Carvalho, Santos Sidney Emanuel Batista dos, Trindade Saide Maria Sarmento, Cardoso Maria do Socorro de Oliveira, Guerreiro João Farias

Abstract excerpt

Increased levels of fetal hemoglobin (HbF, α2γ2) may reduce sickle cell anemia severity due to its ability to inhibit HbS polymerization and also reduce the mean corpuscular HbS concentration. We have investigated the influence of three known major loci on the HbF trait (HBG2, rs748214; BCL11A, rs4671393; and HBS1L-MYB, rs28384513, rs489544 and rs9399137) and HbF levels in SCA patients from the State of Pará,...

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Share to Anemia, Sickle Cell
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Source

Identifiers

PMID: 25084696
DOI: 10.1016/j.bcmd.2014.07.006

Genes

HBG2
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil.PMID 25084696Read ↗

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