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Article

Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.

American journal of hematology - 1 Feb 2012

Akinsheye Idowu, Solovieff Nadia, Ngo Duyen, Malek Anita, Sebastiani Paola, Steinberg Martin H, Chui David H K

Abstract excerpt

Fetal hemoglobin (HbF) is a major modifier of disease severity in sickle cell anemia (SCA). Three major HbF quantitative trait loci (QTL) are known: the Xmn I site upstream of (G)γ- globin gene (HBG2) on chromosome 11p15, BCL11A on chromosome 2p16, and HBS1L-MYB intergenic polymorphism (HMIP) on chromosome 6q23. However, the roles of these QTLs in patients with SCA with uncharacteristically high HbF are not...

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Share to Anemia, Sickle Cell
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to DNA, Intergenic

Share to Fetal Hemoglobin

Share to gamma-Globins

Share to Quantitative Trait Loci

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 22139998
DOI: 10.1002/ajh.22221
PMCID: PMC3302931

Genes

HBD
HBG1
HBG2
MAF
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.PMID 22139998Read ↗

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