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Article

Beta-lactamase dependent and independent evolutionary paths to high-level ampicillin resistance.

Nature communications - 25 Jun 2024

Gross Rotem, Yelin Idan, Lázár Viktória, Datta Manoshi Sen, Kishony Roy

Abstract excerpt

The incidence of beta-lactam resistance among clinical isolates is a major health concern. A key method to study the emergence of antibiotic resistance is adaptive laboratory evolution. However, in the case of the beta-lactam ampicillin, bacteria evolved in laboratory settings do not recapitulate clinical-like resistance levels, hindering efforts to identify major evolutionary paths and their dependency on...

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Identifiers

PMID: 38918379
DOI: 10.1038/s41467-024-49621-2
PMCID: PMC11199616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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