Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering β-lactamase-independent β-lactam resistance evolution trajectories in Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 1 Dec 2018

Cabot Gabriel, Florit-Mendoza Llorenç, Sánchez-Diener Irina, Zamorano Laura, Oliver Antonio

Abstract excerpt

Background: While resistance related to the expression of β-lactamases, such as AmpC from Pseudomonas aeruginosa, has been deeply studied, this work addresses the gap in the knowledge of other potential bacterial strategies to overcome the activity of β-lactams when β-lactamases are not expressed. Methods: We analysed β-lactam resistance evolution trajectories in a WT strain and in isogenic mutants either lacking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Lactam Resistance
Share to beta-Lactamases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Genetic Fitness

Share to Genome, Bacterial

Share to Membrane Transport Proteins

Share to Pseudomonas aeruginosa

Share to Virulence

Source

Identifiers

PMID: 30189050
DOI: 10.1093/jac/dky364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering β-lactamase-independent β-lactam resistance evolution trajectories in Pseudomonas aeruginosa.PMID 30189050Read ↗

Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC.Semantic proximity Read ↗

Mutation-Driven Evolution of Pseudomonas aeruginosa in the Presence of either Ceftazidime or Ceftazidime-Avibactam.Semantic proximity Read ↗

Ceftazidime resistance in Pseudomonas aeruginosa is multigenic and complexSemantic proximity Read ↗

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.Semantic proximity Read ↗

Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in <i>Pseudomonas aeruginosa</i> clinical isolatesSemantic proximity Read ↗

In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA).Semantic proximity Read ↗

Evolutionary trajectories of β-lactam resistance in Enterococcus faecalis strains.Semantic proximity Read ↗

Evolutionary trade-offs between antimicrobial resistance and virulence in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Mutation-driven evolution of <i>Pseudomonas aeruginosa</i> in the presence of either ceftazidime or ceftazidime/avibactamSemantic proximity Read ↗

Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.Semantic proximity Read ↗

In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces <i>Pseudomonas aeruginosa</i> resistance to antipseudomonal antibiotics (APA)Semantic proximity Read ↗

A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved <i>Pseudomonas aeruginosa</i> predict those in naturally evolved bacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.