Article
Non-Mitochondrial Aconitase-2 Mediates the Transcription of Nuclear-Encoded Electron Transport Chain Genes in Fission Yeast.
Journal of microbiology (Seoul, Korea) - 1 Aug 2024
Kim Ho-Jung, Cho Soo-Yeon, Jung Soo-Jin, Cho Yong-Jun, Roe Jung-Hye, Kim Kyoung-Dong
Abstract excerpt
Aconitase-2 (Aco2) is present in the mitochondria, cytosol, and nucleus of fission yeast. To explore its function beyond the well-known role in the mitochondrial tricarboxylic acid (TCA) cycle, we conducted genome-wide profiling using the aco2ΔNLS mutant, which lacks a nuclear localization signal (NLS). The RNA sequencing (RNA-seq) data showed a general downregulation of electron transport chain (ETC) genes in...
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