Article
Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007
Chen Xin Jie, Wang Xiaowen, Butow Ronald A
Abstract excerpt
Aconitase (Aco1p) is a multifunctional protein: It is an enzyme of the tricarboxylic acid cycle. In animal cells, Aco1p also is a cytosolic protein binding to mRNAs to regulate iron metabolism. In yeast, Aco1p was identified as a component of mtDNA nucleoids. Here we show that yeast Aco1p protects mtDNA from excessive accumulation of point mutations and ssDNA breaks and suppresses reductive recombination of...
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