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Article

The metabolic growth limitations of petite cells lacking the mitochondrial genome.

Nature metabolism - 1 Nov 2021

Vowinckel Jakob, Hartl Johannes, Marx Hans, Kerick Martin, Runggatscher Kathrin, Keller Markus A, Mülleder Michael, Day Jason, Weber Manuela, Rinnerthaler Mark, Yu Jason S L, Aulakh Simran Kaur, Lehmann Andrea, Mattanovich Diethard, Timmermann Bernd, Zhang Nianshu, Dunn Cory D, MacRae James I, Breitenbach Michael, Ralser Markus

Abstract excerpt

Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer from severe growth defects. 'Petite yeasts', characterized by mitochondrial genome loss, are instrumental for studying mitochondrial function and physiology. However, the molecular cause of their reduced growth rate remains an open question. Here we show that petite cells suffer from an insufficient capacity to synthesize...

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Identifiers

PMID: 34799698
DOI: 10.1038/s42255-021-00477-6
PMCID: PMC7612105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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