Article
Genome-wide polygenic risk scores predict risk of glioma and molecular subtypes.
Neuro-oncology - 3 Oct 2024
Nakase Taishi, Guerra Geno A, Ostrom Quinn T, Ge Tian, Melin Beatrice S, Wrensch Margaret, Wiencke John K, Jenkins Robert B, Eckel-Passow Jeanette E, Bondy Melissa L, Francis Stephen S, Kachuri Linda
Abstract excerpt
BACKGROUND: Polygenic risk scores (PRS) aggregate the contribution of many risk variants to provide a personalized genetic susceptibility profile. Since sample sizes of glioma genome-wide association studies (GWAS) remain modest, there is a need to efficiently capture genetic risk using available data. METHODS: We applied a method based on continuous shrinkage priors (PRS-CS) to model the joint effects of over 1...
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