Discovery and engineering of ChCas12b for precise genome editing.

doi:10.1016/j.scib.2024.06.012

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Article

Discovery and engineering of ChCas12b for precise genome editing.

Science bulletin - 30 Oct 2024

Wei Jingjing, Liu Jingtong, Tian Yuwen, Wang Ziwen, Hou Linghui, Yang Yuan, Tao Chen, Li Miaomiao, Gao Bao-Qing, Zhou Huanyu, Zheng Xixi, Tang Junnan, Gao Song, Yang Li, Chai Renjie, Wang Yongming

Abstract excerpt

Many clustered regularly interspaced short palindromic repeat and CRISPR-associated protein 12b (CRISPR-Cas12b) nucleases have been computationally identified, yet their potential for genome editing remains largely unexplored. In this study, we conducted a GFP-activation assay screening 13 Cas12b...

Topics

Gene Editing
Humans
CRISPR-Cas Systems
CRISPR-Associated Proteins
HEK293 Cells
RNA, Guide, CRISPR-Cas Systems
Polymorphism, Single Nucleotide
Mutation
Animals

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Open in PubMed

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PMID: 38910106
DOI: 10.1016/j.scib.2024.06.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38910106-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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