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Article

Sex-specific association between infant caudate volumes and a polygenic risk score for major depressive disorder.

Journal of neuroscience research - 1 Dec 2020

Acosta Henriette, Kantojärvi Katri, Tuulari Jetro J, Lewis John D, Hashempour Niloofar, Scheinin Noora M, Lehtola Satu J, Fonov Vladimir S, Collins D Louis, Evans Alan, Parkkola Riitta, Lähdesmäki Tuire, Saunavaara Jani, Merisaari Harri, Karlsson Linnea, Paunio Tiina, Karlsson Hasse

Abstract excerpt

Polygenic risk scores for major depressive disorder (PRS-MDD) have been identified in large genome-wide association studies, and recent findings suggest that PRS-MDD might interact with environmental risk factors to shape human limbic brain development as early as in the prenatal period. Striatal structures are crucially involved in depression; however, the association of PRS-MDD with infant striatal volumes is...

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Identifiers

PMID: 32901998
DOI: 10.1002/jnr.24722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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