Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders.

Molecular psychiatry - 1 Jul 2026

Giacomel Alessio, Powell Timothy R, Duarte Rodrigo R R, Nordio Giovanna, Williams Steve C R, Turkheimer Federico, Veronese Mattia, Martins Daniel, Dima Danai

Abstract excerpt

Psychiatric disorders are complex, polygenic conditions characterized by patterned structural brain alterations. Whether these changes reflect transcriptional dysregulation driven by genetic risk remains unclear. We introduce a novel imaging-transcriptomics framework that integrates transcriptome-wide association studies (TWAS) with brain transcriptomic atlases to predict macroscale structural brain abnormalities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anorexia Nervosa
Share to Attention Deficit Disorder with Hyperactivity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Autism Spectrum Disorder

Share to Brain Mapping

Share to Genetic Risk Score

Share to Major Depressive Disorder

Share to Mental Disorders

Share to Obsessive-Compulsive Disorder

Source

Identifiers

PMID: 41792457
DOI: 10.1038/s41380-026-03497-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders.PMID 41792457Read ↗

Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive DisorderSemantic proximity Read ↗

Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.Semantic proximity Read ↗

Spatiotemporal Brain Transcriptomics Reveal Risk Gene Hot-Spots in Major Neuropsychiatric DisordersSemantic proximity Read ↗

Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.Semantic proximity Read ↗

A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health.Semantic proximity Read ↗

Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traitsSemantic proximity Read ↗

Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits.Semantic proximity Read ↗

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.Semantic proximity Read ↗

Structural and cellular transcriptome foundations of human brain diseaseSemantic proximity Read ↗

Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traitsSemantic proximity Read ↗

A pattern of continuity from health to disease in neuropsychiatric genetic risk affecting brain morphologySemantic proximity Read ↗

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlapSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.