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Article

Driving the wedge: Understanding an improved Cas9 to better engineer others.

Molecular cell - 20 Jun 2024

Lenihan Charles J, Bailey Scott

Abstract excerpt

In their recent structural work, Eggers et al.1 rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.

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Source

Identifiers

PMID: 38906114
DOI: 10.1016/j.molcel.2024.05.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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