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Article

Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.

The Lancet. Respiratory medicine - 1 Aug 2013

Belsky Daniel W, Sears Malcolm R, Hancox Robert J, Harrington Honalee, Houts Renate, Moffitt Terrie E, Sugden Karen, Williams Benjamin, Poulton Richie, Caspi Avshalom

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have discovered genetic variants that predispose individuals to asthma. To integrate these new discoveries with emerging models of asthma pathobiology, we aimed to test how genetic discoveries relate to developmental and biological characteristics of asthma. METHODS: In this prospective longitudinal study, we investigated a multilocus profile of genetic risk...

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Asthma
Child
Genome-Wide Association Study
Longitudinal Studies
Multifactorial Inheritance

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PMID: 24429243
DOI: 10.1016/S2213-2600(13)70101-2
PMCID: PMC3899706

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