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Systemic interleukin signaling and Alzheimer's disease risk: A two-sample cross-replication Mendelian randomization study.

Journal of Alzheimer's disease : JAD - 1 Jul 2026

Ahmed Hafiz M, Ali Siddique M, Shaheer Ul Islam M, Khan Lodhi Abdul Rafay, Owais Muhammad, Rehman Ubaid Ur

Abstract excerpt

BackgroundAlzheimer's disease (AD) is the leading cause of dementia worldwide, yet no disease-modifying therapy exists. Systemic inflammation has been proposed as a causal factor, supported by observational studies reporting elevated plasma interleukins in AD, though such studies cannot establish causality. Recent evidence instead highlights local neuroinflammation and microglial dysfunction as key...

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PMID: 42116542
DOI: 10.1177/13872877261449516

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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