Article
Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Eriksson Ulrika K, Pedersen Nancy L, Reynolds Chandra A, Hong Mun-Gwan, Prince Jonathan A, Gatz Margaret, Dickman Paul W, Bennet Anna M
Abstract excerpt
Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and dementia. We therefore sought to study DNA sequence variation and serum levels of the potent inflammatory mediators Interleukin-6 (IL6) and C-reactive protein (CRP) in relation to AD and dementia. Tagging single nucleotide polymorphisms (tagSNPs) were chosen to capture most variation in and around CRP and IL6 in 3937 elderly Swedish men...
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