Article
Diet, sex, and genetic predisposition to obesity and type 2 diabetes modulate motor and anxiety-related behaviors in mice, and alter cerebellar gene expression.
Behavioural brain research - 8 May 2023
Grover Lawrence, Sklioutovskaya-Lopez Kristiana, Parkman Jacaline K, Wang Katherine, Hendricks Emily, Adams-Duffield Jessica, Kim Jung Han
Abstract excerpt
Obesity and type 2 diabetes (T2D) are serious health problems linked to neurobehavioral alterations. We compared motor function, anxiety-related behavior, and cerebellar gene expression in TALLYHO/Jng (TH), a polygenic model prone to insulin resistance, obesity, and T2D, and normal C57BL/6 J (B6) mice. Male and female mice were weaned onto chow or high fat (HF) diet at 4 weeks of age (wk), and experiments...
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