Article
Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy.
Disease models & mechanisms - 18 Dec 2018
O'Brien Phillipe D, Hinder Lucy M, Rumora Amy E, Hayes John M, Dauch Jacqueline R, Backus Carey, Mendelson Faye E, Feldman Eva L
Abstract excerpt
Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice, 5-week-old male C57BL/6J mice were fed a high-fat diet to induce diet-induced obesity (DIO), a model of prediabetes, and a cohort of these animals was injected with low-dose streptozotocin (STZ) at 12 weeks of age to induce hyperglycemia and type 2 diabetes....
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