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Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential

28 Jul 2025

Abstract excerpt

Purinergic signaling, mediated by extracellular ATP (eATP) and P2 receptors, plays a vital role in physiological and pathological processes. The P2X7 receptor (P2X7R), a ligand-gated cation channel, is crucial in inflammation, cell death, and immune responses. Widely expressed in retinal cells, P2X7R contributes to visual function regulation and retinal degeneration. This review explores P2X7R involvement in...

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Share to Adenosine and Purinergic Signaling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40729957
DOI: 10.1016/j.mam.2025.101389

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