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Article

Mutations found in cancer patients compromise DNA binding of the winged helix protein STK19.

Scientific reports - 18 Jun 2024

Li Jian, Ma Xinli, Wang Xiaoyu, Hu Xiaotong, Fang Shaobo, Jin Guoguo, Liu Kangdong, Dong Zigang

Abstract excerpt

Serine/threonine protein kinase 19 (STK19) has been reported to phosphorylate and activate oncogenic NRAS to promote melanomagenesis. However, concerns have been raised about whether STK19 is a kinase. STK19 has also been identified as a putative factor involved in the transcription-coupled nucleotide excision repair (TC-NER) pathway. In this study, we determined the 1.32 Å crystal structure of human STK19. The...

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Identifiers

PMID: 38890355
DOI: 10.1038/s41598-024-64840-9
PMCID: PMC11189558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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