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Article

Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.

Molecular cell - 27 Feb 2009

Wang Yu, Reddy Bharat, Thompson James, Wang Hengbin, Noma Ken-ichi, Yates John R, Jia Songtao

Abstract excerpt

Methylation of histone H4 lysine 20 (H4K20me) is essential for recruiting checkpoint proteins 53BP1/Crb2 to DNA lesions and subsequent activation of a DNA-damage checkpoint. In fission yeast, Set9 (spKMT5) catalyzes mono-, di-, and trimethylation of H4K20. However, the mechanisms that regulate Set9 function are poorly understood. Here, we identified a PWWP domain protein Pdp1 as a Set9-associated factor. Pdp1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19250904
DOI: 10.1016/j.molcel.2009.02.002
PMCID: PMC2673476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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