Article
Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.
Cell - 11 Jun 2020
Rodríguez-Martínez Marta, Boissiére Thierry, Noe Gonzalez Melvin, Litchfield Kevin, Mitter Richard, Walker Jane, Kjœr Svend, Ismail Mohamed, Downward Julian, Swanton Charles, Svejstrup Jesper Q
Abstract excerpt
STK19 was proposed to be a cancer driver, and recent work by Yin et al. (2019) in Cell suggested that the frequently recurring STK19 D89N substitution represents a gain-of-function change, allowing increased phosphorylation of NRAS to enhance melanocyte transformation. Here we show that the STK19 gene has been incorrectly annotated, and that the expressed protein is 110 amino acids shorter than indicated by...
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