Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions.

Journal of bacteriology - 1 Jan 2012

Haydel Shelley E, Malhotra Vandana, Cornelison Garrett L, Clark-Curtiss Josephine E

Abstract excerpt

The Mycobacterium tuberculosis prrA-prrB (Rv0903c-Rv0902c) two-component regulatory system is expressed during intracellular growth in human macrophages and is required for early intracellular multiplication in murine macrophages, suggesting its importance in establishing infection. To better understand the function of the prrA-prrB two-component system, we defined the transcriptional characteristics of the prrA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium tuberculosis

Share to Nitrogen

Share to Operon

Share to Oxygen Consumption

Share to Transcription, Genetic

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 22081401
DOI: 10.1128/JB.06258-11
PMCID: PMC3256671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions.PMID 22081401Read ↗

Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis.Semantic proximity Read ↗

Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatisSemantic proximity Read ↗

Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis.Semantic proximity Read ↗

An Essential Two-Component Signal Transduction System in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Two-Component Regulatory Systems of MycobacteriaSemantic proximity Read ↗

Transcriptional and Physiological Changes during Mycobacterium tuberculosis Reactivation from Non-replicating PersistenceSemantic proximity Read ↗

Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis.Semantic proximity Read ↗

The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice.Semantic proximity Read ↗

M. tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia.Semantic proximity Read ↗

A transposon insertion mutant of Mycobacterium fortuitum attenuated in virulence and persistence in a murine infection model that is complemented by Rv3291c of Mycobacterium tuberculosis.Semantic proximity Read ↗

Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.Semantic proximity Read ↗

Global mapping of MtrA-binding sites links MtrA to regulation of its targets in Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.