Article
A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties.
PloS one - 1 Jan 2021
Waturuocha Uchenna Watson, P J Athira, Singh Krishna Kumar, Malhotra Vandana, Krishna M S, Saini Deepak Kumar
Abstract excerpt
The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. Although the lineages of these clinical strains can be traced back to common ancestor/s, there exists a plethora of difference between them, compared to those that have evolved in the laboratory. We identify a mutation present in ~80% of clinical strains, which maps in the...
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